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Clomiphene citrate (Clomid) has been used for more than 40 years. Your doctor may prescribe it if you’re not ovulating normally.

Clomid and Serophene, the brand names of clomiphene, are known as estrogen-blocking drugs. They cause the hypothalamus and pituitary gland, located in your brain, to release hormones called GnRH (gonadotropin-releasing hormone), FSH (follicle-stimulating hormone) and LH (luteinizing hormone). These hormones trigger your ovaries to make eggs.

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How well it works: About 60% to 80% of women who take clomiphene will ovulate, and about half will be able to get pregnant. Most pregnancies happen within three cycles.

Side effects: They’re generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache.

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